Für den Inhalt der Angaben zeichnet die Projektleitung verantwortlich.
This project is one of the five winners of the call 2016 «Microbials – Direct Use of Micro-Organisms».
Project partners: CHUV, Service de pneumologie; University of Lausanne, Department of Fundamental Microbiology; Oslo University Hospital
Project no: GRS-055/16
Amount of funding: CHF 480'000
Duration: 01.2017 - 01.2020
Area of activity:
Microbials, seit 2016
Assoc. Prof. Dr. Benjamin Marsland
Centre hospitalier universitaire vaudois (CHUV)
Service de pneumologie, Dept. of Medicine
Bureau CLE D02-206, Ch. des Boveresses
1066 Epalinges (Schweiz)
- benjamin.marsland@chuv. ch
In western societies there has been a striking increase in the incidence of inflammatory diseases such as asthma, autoimmunity and inflammatory bowel disease over recent decades. The general consensus in the field is that major underlying causes of this increase are changes in lifestyle, diet and hygiene. A commonality between all of these factors is shifts in the constituents of the microbiota. Accordingly, there has been a surge of interest in trying to manipulate the microbiota with bacterial pre- or pro-biotics, for example, as a means of improving human health. Based upon preliminary data, we propose that bacteria are only one aspect of this phenomenon, and that fungi represent an untapped resource for shaping the microbiome and consequently disease susceptibility and development. In this project proposal we aim to identify which fungi in mice and humans are responsible for influencing inflammatory diseases, such as asthma. We aim to decipher the mechanisms through which fungi impact upon disease and to perform preclinical efficacy studies to establish which fungi hold the greatest promise for further development as novel future therapeutics. To achieve these goals, we plan to take an interdisciplinary approach incorporating preclinical immunology, computational modeling and a clinical cohort. Our hypotheses are based upon preliminary data and we have established the required models and collaborations in order to achieve our goals. Therapeutic targeting of the fungal ‘mycobiome’ could be the step-change needed to reduce inflammatory diseases, improve human health and lower the burden that these diseases place upon society and healthcare systems.
What is special about the project?
This is a highly innovative and unique project addressing a new concept in microbiome research–harnessing fungi for their therapeutic potential. The approach is interdisciplinary, with a cross-over between immunology, clinical studies and computational modeling approaches.
A model has been generated whereby mice are depleted of fungi and we see they become more susceptible to asthma. By next generation sequencing and in vivo colonization approaches we have identified Candida albicans as a fungus that can increase susceptibility to asthma. We are searching for fungi and bacteria that will protect against asthma.
None so far
None so far
Persons involved in the project
Dr. Benjamin Marsland
, Associate Professor, project leader, Chef de secteur de recherche, phone +41 (0)21 314 1378, mobile +41 (0)79 556 1459
Last update to this project presentation 23.03.2020