Für den Inhalt der Angaben zeichnet die Projektleitung verantwortlich.
Dieses von der Gebert Rüf Stiftung geförderte Projekt wird von folgenden weiteren Projektpartnern mitgetragen:
EPFL – Laboratory of Microsystems (LMIS2)
EPFL – Laboratory of Integrative Systems Physiology (LISP)
ECAL (Ecole cantonale d'art de Lausanne)
Förderbeitrag: CHF 92'000
Dauer: 10.2018 - 09.2019
Handlungsfeld: DesignPlus, 2013 - 2018
Dr. Matteo Cornaglia
Ecole Polytechnique Fédérale de Lausanne
Microsystems and Microelectronics
EPFL-STI-IMT-LMIS2, BM3135, Station 17
1015 Lausanne (Schweiz)
- matteo.cornaglia@epfl. ch
Nagi Bioscience aims to revolutionize the way toxic and/or beneficial effects of substances can be tested, by introducing the first “Organism-on-Chip” technology. Our patented solution combines the use of microscopic worms as in vivo models for drug/chemical screening with the first technological platform for their fully automated in vitro culture, treatment and high-content analysis. Supported by the Gebert Rüf Stiftung grant “Nematrix Technologies”, the first prototype of this disruptive technology is today operational. The next challenge is to transform this prototype from a functional assembly of laboratory components into an integrated user-friendly device, ready to be transferred to partner laboratories for beta testing and aiming to set a novel industry standard in the near future. To allow for its correct adoption by external users, the device will have to be structured as a compact benchtop machine, provided with a plug-and-play interface with interchangeable microfluidic chips. The device format must be modular and versatile, readily adaptable to different throughput and testing specification requirements. This project aims thus to define all the key elements of such an industrial device, namely: (i) user-experience design and the flow of actions for the device use; (ii) anticipation of possible user misuses and implementation of preventive measures in the device construction; (iii) integration strategy and ergonomics; (iv) a user-friendly, seamless hardware/software interface.
Was ist das Besondere an diesem Projekt?
By combining the advantages of a highly validated biological model with the unprecedented automation possibilities offered by our future device, the Nagi Bioscience Design+ project aims to set a new standard among the technological tools offering alternative opportunities to traditional animal testing. In fact, the “Organism-on-Chip” device is meant to perfectly fill the current gap between cell-based (in vitro) and mice-based (in vivo) assay technologies. On the one hand, C. elegans provides a complete and reliable in vivo model, allowing the assessment of complex biological responses at whole-organism level, which are typically not observable using cell-based methods. On the other hand, our “worm assays” will be performed at high-throughput-like scales of automation and standardization, which is key to attain the throughput and reliability standards requested by industrial applications.
The project content has been defined – and will be executed – together with recent graduate designers from the École cantonale d'art de Lausanne (ECAL), who perfectly complement the skills of our multidisciplinary team at EPFL, built at the interface between microtechnology, biology and robotics. Aims and outcomes of the project have been moreover discussed with biologists from EPFL and UNIL, as first beta testers of the future device, and with experts from major industrial groups within our target markets, interested in potential partnerships at the end of this project.
Am Projekt beteiligte Personen
, PhD Microtechnology, EPFLLaurent Mouchiroud
, PhD biology, Lyon IFabien Tâche
, PhD robotics, ETHSumegha Mantri
, MA product design, ECAL
AdvisorsProf. Dr. Martin Gijs
, PI at EPFL/LMIS2Prof. Dr. med. Johan Auwerx
, PI at EPFL/LISPProf. Lluis Fajas Coll
, PI at UNIL/CIG
Letzte Aktualisierung dieser Projektdarstellung 15.04.2019