The face is the gateway to a person's soul. Even the slightest deformity of facial features outside the range perceived to be 'normal' can cause sociopsychological problems. Children born with severe cranofacial defects, for example arhinia, hemifacial microsomies or Treacher-Collins syndrome, suffer much more. They need to undergo in excess of twenty operations to correct breathing, hearing, eating and speech function as well as additional procedures to reconstruct contours of the face. To make treatment even more challenging, these syndromes express themselves in varying grades of severity in each patient and in each tissue type, and thus a unique and individualized reconstruction must be planned for each child.
Due to the growth of the face and its complex contours, the procedures to treat these craniofacial syndromes are amongst the most challenging in reconstructive surgery. The surgeries currently rely on the harvest of the patient’s fascial flaps, bone, muscle, fat and skin for reconstruction which poses additional burden on the child.
We propose a unique and high-technology solution for the design and fabrication of individualized craniofacial grafts for children born with craniofacial defects, thus eliminating some of the need for tissue harvesting. The goals of this project are:
1. The development of a statistical shape model which encompasses the naturally occurring variation in facial anatomy and bone structure of healthy, growing children.
2. The design of 3D models to restore nasal and soft tissue structures in patients with craniofacial defects
3. The advanced manufacture of hybrid which are texturally realistic, biocompatible, and mechanically robuimpimst
4. The pre-clinical evaluation of these grafts.
We develop a toolbox of software and biofabrication processing methods and materials which could one day be used to treat children afflicted by these serious craniofacial conditions. These methods may can also be used for patient’s whose face has been deformed by cancer or trauma. An innovative feature of this project is the collaboration between computer scientists, bioengineers, medical doctors and entrepreneurs. Finally, transfer of these design principles to higher education is a big part in the project. Prof Vetter leads an international course on Probabilistic Morphable Shape Models. “Practical Methods in Biofabrication” is a new course being taught by Prof. Zenobi-Wong at ETH Zürich which has been running since 2018. Both courses incorporate findings from this project and thereby strengthen Swiss education in these cutting-edge fields of biofabrication and anatomical computer modelling.
Was ist das Besondere an diesem Projekt?
The goals of the project are completely unique. Up until now the only treatment possible for people with severe craniofacial malformations such as a missing nose, are fabrication of silicone prosthesis held to the face through magnetic pins. These implants are never accepted by the wearer as part of their body, but only as a foreign object. Scientific creativity is required in designing the missing or underdeveloped features to enhance the overall aesthetics of the face. Creativity is also required to come up with new combinations of biomaterials (hybrid implants) to fulfill the complex requirements of the surgical site and which may one day be able to grow in size and shape as the child grows. This project combines aesthetics, computer science, material science and processing to achieve innovative medical products. Technically, modelling face surface and soft tissue under the constraint of the skull development of growing children has never been reported and the development of a detailed model of a growing child's face and skull is one of the truly innovative aspects of the the project. Our recent work includes a statistical shape model of a growing skull and the development of novel casting methods which allow patient-specific, yet simple manufacture. These tools will aid immensely in the work of reconstructive surgeons to plan surgical procedures and achieve better aesthetic outcome.
Zenobi-Wong laboratory for Tissue Engineering + Biofabrication is unique in that it combines expertise from cartilage cell biology, biomaterials synthesis and characterization, and biofabrication techniques including bioprinting, electrospinning and two-photon patterning. This team possesses both the depth and breadth in cartilage tissue engineering which is unique world-wide. In addition, the Zenobi lab has pioneered 3D bioprinting and biofabrication of human auricular cartilage, intended to treat children with microtia.
The Vetter lab for Computer Graphics and Computer Vision pioneered the development and application of 3D statistical shape models of the human face. Over the years the methodology was extended to bones of the human skeleton including models of the skull as well as to soft tissue and inner organs. The approach taken is unique by combining machine learning technologies with geometric modeling. The method is capable to model the range of normal appearance, to detect pathologies as well as to predict the shape of missing parts. Internationally the approach is well received, what is also demonstrated by the high number of researchers which actively pursued and finished our recent open online course.
Tosoratti, E, Guillon, P, Kessel, B, Zenobi-Wong, M Eluting Moulds for Hydrogel Crosslinking, European Patent EP 19169134
None so far
Am Projekt beteiligte Personen
Prof. Marcy Zenobi-Wong
, project leader, Dept Health Sciences & Technology, ETH Zürich
Dr. Pierre Guillon, Dept Health Sciences & Technology, ETH Zürich
Prof Thomas Vetter, Dept. Mathematics and Computer Science, University of Basel
Dr. Ghazi Bouabene, Dept. Mathematics and Computer Science, University of Basel
Enrico Tosoratti: PhD Student from ETHZ
Dennis Madsen: PhD Student from Basel
Prof Christian Kellenberger, Head of Radiology, Zürich Children's Hospital
Letzte Aktualisierung dieser Projektdarstellung 25.06.2019