Für den Inhalt der Angaben zeichnet die Projektleitung verantwortlich.
Dieses von der Gebert Rüf Stiftung geförderte Projekt wird von folgenden weiteren Projektpartnern mitgetragen: Laboratory of Stem Cell Bioengineering, Life Science Department, EPF Lausanne; Département Femme-Mère-Enfant, CHUV, Lausanne; CTI; Bridge – SNSF/CTI
Förderbeitrag: CHF 354'000
Dauer: 10.2017 - 05.2019
Handlungsfeld: Pilotprojekte, 1998 - 2018
PhD Hans Mattias Larsson
Ecole Polytechnique Fédérale de Lausanne
Institute of Bioengineering, Laboratory of stem cell bioengineeering
AI 1106, Station 15
1015 Lausanne (Schweiz)
- mattiashans.larsson@epfl. ch
Stress urinary incontinence is a disease that touches 1 in 5 women over the age of 40 and 1 in 10 women after childbirth. Incontinence is the involuntary leakage of urine that can happen anywhere and anytime in daily life when you are laughing, coughing, sneezing, or exercising. Stress urinary incontinence is due to a muscle problem. The pelvic floor and/or the sphincter muscle are not strong enough anymore to efficiently close the urethra when the intra-abdominal pressure suddenly increases. Nowadays available surgical therapies only treat the symptoms but not the cause of stress urinary incontinence. The so-called sling procedure is efficient but carries risks of serious complications, whereas the injection of Bulkamid is a minimal invasive intervention with a low risk of complications but the treatment is not very efficient on a long-term. Therefore, our aim is to develop a new injectable, minimal invasive therapy for stress urinary incontinence that strengthens the weak muscles to achieve a long-lasting relief for the patients with a low risk of complications.
The project funded by the Gebert Ruef foundation will help us to design the prototype in a rabbit model and to evaluate its functionality in a mini pig model. A successful completion of the project will result in the incorporation of our start-up company.
Was ist das Besondere an diesem Projekt?
The novelty of our therapy is that it induces neo-muscle tissue formation. Our material is injected in the same way as Bulkamid and forms, as Bulkamid does, a stable bulk in the submucosal space of the urethra. The bulk reduces the inner diameter of the urethra and therefore the patient feels an immediate relief. The action of Bulkamid stops here. However, the bulk created by our material induces neo-muscle formation, so that the degrading bulk is replaced over time by new functional muscle tissue. The new muscle tissue strengthens the weak sphincter muscle achieving a long-lasting continence. Therefore, our therapy not only treats the symptom of stress urinary incontinence but also the cause.
The project has completed the first project phase being a proof of concept study in a rabbit model. The injected material formed a bulk at the injection site and 74% of the initial bulk volume was still present three months post-injection. At the same time point approximately 24% of the bulk was populated with smooth muscle cells showing a contractile phenotype. After the successful study in rabbits, the material will be evaluated in a mini pig model during the second project phase.
The patent describing the production of the injectable material entered into the national phase in Europe and in the US in May 2018.
The preparations to create a start-up are ongoing. The team is currently preparing a business plan, a preliminary risk analysis, and a literature review for the clinical evaluation plan. To get support with the business creation, the team will participate at the Venture Kick this summer and is planning to subscribe to the start-up coaching of Innosuisse.
E. Vardar et al. (2018). «Microfluidic production of bioactive fibrin micro-beads embedded in crosslinked collagen used as an injectable bulking agent for urinary incontinence treatment.» Acta Biomater 67:156-166
Venture.ch business idea competition 2016, amongst the Top5; access via venture.ch
TERMIS business plan completion 2016, winner; access via termis.org/eu2016
Venture Leader Life Sciene event Boston 2017
Am Projekt beteiligte Personen
Letzte Aktualisierung dieser Projektdarstellung 17.04.2019